Edvotek “Mystery of the Crooked Cell” – Sickle Cell Anemia Electrophoresis Simulation Kit

The Edvotek Mystery of the Crooked Cell Kit offers an accessible and engaging way to explore the genetics and molecular basis of Sickle Cell Anemia. This hands‑on laboratory activity uses a safe dye‑based simulation to demonstrate how electrophoresis can be used to detect genetic mutations associated with the disease. Students will separate colourful, Ready‑to‑Load™ dye samples that represent patient and control DNA profiles, making it an ideal introduction to biotechnology techniques.

Designed for up to 10 agarose gels, this kit provides comprehensive materials, including agarose powder, electrophoresis buffer, microtipped pipettes, practice loading solution, and full instructions. Simply add an electrophoresis chamber, power supply, and a heat source (microwave or hot plate) to begin.

Key Features

• Hands‑on simulation demonstrating detection of the Sickle Cell mutation
• Uses dye‑based electrophoresis for a safe, classroom‑friendly experience
• Includes Ready‑to‑Load™ dye samples representing patient and control profiles
• Supplied with agarose powder to prepare 10 student gels
• Contains practice gel‑loading solution to help students build pipetting confidence
• Includes electrophoresis buffer and microtipped transfer pipettes
• Clear, easy‑to‑follow teacher and student instructions
• Ideal for biology classes exploring genetics, inheritance, and molecular biology techniques

You Need: electrophoresis apparatus, power supply, microwave or hot plate.

Ideal for School Science Lessons & Biotechnology Teaching

Perfect for KS4, GCSE, and A‑Level Biology, this kit helps students visualise how DNA mutations can be detected using laboratory methods. It connects molecular genetics to real‑world medical conditions, supporting curriculum topics such as:

• Sickle Cell Anemia and genetic disorders
• Protein structure and point mutations
• Electrophoresis principles and how charged molecules move through a gel
• Analysing genetic test results using patient “samples”
• Developing practical skills such as gel preparation, pipetting, and data interpretation

Engaging, safe, and scientifically accurate, the Mystery of the Crooked Cell kit transforms complex genetic concepts into a meaningful, hands‑on laboratory experience that builds confidence and curiosity in students.